| Biphasic Signals
Because ions dissociate
by electrolysis in the presence of
electrical current, living tissue
can become polarized in a direct current
field. This can be disastrous in neuronal
tissue. Therefore, modern stimulators
usually provide alternating or biphasic
current. That is, current that reverses
polarity each half cycle so that the
electrolytes factor sum to zero. If
the current continued to flow in the
same direction, polarity stress could
result in irreversible tissue damage.
As an analogy, picture
a group of soldiers marching across
a bridge. Before they get to one side,
an about face order is given and they
return. Before they reach the opposite
side, another about face order is
given, and so on, so that they never
actually reach a side. By going back
and forth, biphasically, there is
no net electron flow across the bridge
and no soldiers are added or subtracted.
They never get across the bridge to
cause an irreversible balance in the
status quo.
Since the first edition
of this book a few engineers have
commented that biphasic is incorrect
and should be replaced with bipolar.
Technically, this is true but the
designation of biphasic has already
become the usual and customary term
in electromedicine, so we have maintained
it.
Amperage, Voltage
and Resistance
Electricity travels
in a circuit. The number of electrons
moving per unit of time is called
amperage. This is a measure of the
amount of current. Voltage is a measure
of the pressure in the circuit. Resistance
to the electron flow in the circuit
is measured in Ohms. A classic analogy
of this is a garden hose setup. The
amount of water in the hose would
correspond to the amperage. The water
pressure would correspond to the voltage.
The hose could only take so much water
pressure at a given time. Any more
pressure or water would be met by
more resistance from the hose. This
concept has been mathematically related
by Ohm's law of E = IR, where E is
the voltage, I is the current and
R is the resistance. One can increase
the current and decrease the voltage
by decreasing resistance, just as
more water could pass with a lower
pressure through a fire hose instead
of a garden hose. Similarly, more
current can pass through a larger
diameter wire or through a highly
conductive metal such as copper. In
both cases, the thicker wire and more
conductive metal have lower resistance.
In the case of a
human body, resistance is determined
by factors such as fluid content,
general health, skin thickness, amount
of oil on the skin, humidity in the
air, etc. If a person has a higher
resistance, less current will flow
through. The voltage can be raised
to maintain the desired level of current.
The better electromedical devices
deliver a constant current by self-adjusting
the voltage as the skin resistance
changes.
CLINICAL ASPECTS
OF ELECTROMEDICINE
The correct form
of electromedicine will have a profound
and usually immediate effect on pain.
Although caution is advised during
pregnancy and electrical stimulation
should not be used on patients with
demand type cardiac pacemakers, there
are no known significant adverse side
effects to therapeutic electromedical
technology.
TRANSCUTANEOUS
ELECTRICAL NERVE STIMULATION
Our understanding
of pain mechanisms and how pain is
perceived has undergone significant
changes. Initially, pain was viewed
as an emotion rather than a sensation.
It was said to be the opposite of
pleasure. This theory dated back to
the time of Aristotle. The traditional
theory, described as the specificity
theory by Descartes in 1664, conceived
of a pain system as a direct channel
from the skin to the brain (Melzack
& Wall, 1982). This concept was
supported and expanded on by Von Frey,
who argued that there were specific
pain receptors (Sinclair, 1953). As
scientific experimentation grew towards
the later part of the last century,
Goldscheider developed the pattern
theory, which stated that sensation
was based on spatial and temporal
patterns of a number of impulses (Nafe,
1929; Geldard, 1953).
Zotterman (1936)
discerned A-Delta and C afferent nerve
fibers. Later research stated that
A-delta fibers carried fast, but short-lived,
well-defined pain impulses while C
fibers carried slow, diffuse, long-duration
pain.
The modern basis
for the widespread use of transcutaneous
electrical nerve stimulation (TENS)
for pain control is the gate control
theory proposed by Dr. Ronald Melzack
and Dr. Patrick Wall (1965). This
theory suggests that hypothetical
"gates" in lamina V of the substantia
gelatinosa could be "closed" to block
pain stimuli traveling from A-delta
and C fibers in the peripheral nervous
system where they synapse into the
central nervous system. Although this
theory was later modified, it created
much notoriety at the time and revolutionized
the way most practitioners viewed
and treated chronic pain.
In 1967, C. Norman
Shealy, M.D., a neurosurgeon who had
been implanting dorsal column stimulators
(DCS), discovered that devices that
transmitted electricity transcutaneously
were just as effective without the
risks associated with surgery (Shealy,
Mortimer, & Reswich, 1967). With
the Melzack-Wall theory behind him,
Shealy's work renewed interest in
electromedicine and resulted in the
beginning of the modern day TENS devices.
Transcutaneous electrical
nerve stimulation is an established
modality with over 250,000 TENS units
prescribed annually in the United
States alone. Accordingly, much information
is available on standard TENS applications,
precautions, contraindications, side
effects and results (Mannheimer &
Lampe, 1984; Tapio & Hymes, 1987).
Mixed results have
occurred due to several factors, such
as waveform, frequency, pulse repetition
rate, intensity, alternating vs. direct
current, electrode placement and treatment
time. Perhaps the single largest variable
is the education, or lack thereof,
provided to health care practitioners
recommending these devices and instructing
patients in their use. Many professionals
simply give the unit to a patient
with the factory settings and never
alter them, leaving each device as
a hit or miss item. TENS devices must
be tried at a variety of settings
to achieve optimal pain relief for
a given patient.
In principle, TENS
applies an electrical force that stimulates
pain-suppressing A-beta afferent nerve
fibers which compete against pain-carrying
afferent nerve fibers. The same stimulation
would occur if one lightly tapped
the painful body part repeatedly with
a pen, spoon, or other blunt object.
Ice, massage, heat, manipulation and
other long-standing therapy techniques
have relieved pain this way for centuries.
Energy Source
Most TENS units
work with currents in the milliampere
range delivered for about 250 microseconds.
The most common output is biphasic
to avoid the side effects of polarization.
They are powered either by alkaline
or nickel cadmium batteries. In general,
alkaline batteries are preferred for
constant stimulation because they
have a relatively slow, linear power
decay. Rechargeable batteries have
a series of peaks or near-peaks in
their discharge rate because each
cell discharges in series. Accordingly,
rechargeable batteries should be avoided,
especially in the cheaply made Taiwanese
devices.
Electrodes
Initially, dry
pads were provided that required the
use of a gel. This was messy, provided
uneven conductivity and caused minor
skin burns at a high current. At present,
self-adhesive electrodes are available
that are semi-disposable and generally
affordable. In this day and age of
concern over deadly infectious diseases,
it has become common practice for
clinicians to keep a separate set
of electrodes for the exclusive use
of each patient.
Pulse Repetition Rate (PRR)
The reader will
often see this listed as "frequency"
on a typical TENS unit. According
to the previous discussion in this
chapter, the lower the PRR setting,
the greater number of frequencies
the patient will be exposed to; hence,
the greater potential for pain relief.
For the average pain patient, we recommend
setting the PRR to the lowest setting
for initial trials. Pomerantz (1981)
has also shown by naloxone blocking
studies that endorphins are only released
at PRR settings of 8 Hertz or less.
Pulse Width
Wider pulses spread
the current over greater distances.
The maximum parameters in most TENS
units ranges from 50 to 400 microseconds.
The further apart the electrodes are,
the wider the pulse width should be.
Electrode Placement
Electrode placement
is perhaps the greatest variable in
eliciting successful results with
TENS. Electrodes can be placed "between
the pain and the brain," along nerve
roots, dermatomes of the respective
nerve levels, following the referred
pain pathway, or on trigger points.
Janet Travell, M.D.
started researching trigger points
in 1957 (Travell & Simons, 1983).
Trigger points are named such because
they trigger pain when pressed. They
are areas of localized tenderness
that usually form with a persistent
muscle spasm. For the purpose of this
discussion, they can be measured as
having higher conductivity than normal
tissue. In most cases, electrical
treatment directly on the point is
indicated. Sometimes, this will increase
the pain (as explained by the pattern
theory of pain). If this occurs, treating
across the area with microcurrent
stimulation at 0.5 Hz will almost
always alleviate it. With the parameters
discussed, it is apparent that several
combinations of PRR, pulse width,
intensity, electrode placement, time
and frequency of stimulation may have
to be attempted before desirable results
are obtained. Perhaps this is the
reason why most major medical insurance
companies prefer to rent a TENS device
to a patient for the first month before
approving it for purchase.
Indications
Several studies
have documented the desirable effects
of TENS. Loeser and his coworkers
(1975) examined TENS-induced relief
of pain for headaches, cervical arthritis,
low back, phantom limb, arthritis
and acute post-operative pain. Tapio
and Hymes (1987) reviewed the efficacy
of TENS on low-back pain, cancer pain,
post-herpetic neuralgia, phantom limb
pain, rheumatoid arthritis, angina
pectoris, various acute conditions,
dysmenorrhea, visceral pain and several
other disorders. Andersson (1976)
found TENS could raise the threshold
for dental pain. By using low-frequency,
high-intensity stimulation (the so-called
"acupuncture-like TENS") he was able
to increase his success rate in pain
reduction from 40 to 60%.
Contraindications
There are very
few contraindications with TENS. All
electrical modalities are contraindicated
for pregnant women and patients with
demand-type pacemakers. In general
it is advisable that patients not
drive or operate heavy machinery while
TENS is being applied. Also, it is
essential that electrodes from milliampere
TENS units are not placed on the head
or neck. This is especially true regarding
the carotid sinuses as stimulation
of the baroreceptors may result in
a vaso-vagal syncopé.
TENS Summary
TENS is now a widely used modality
for the treatment of general acute
and chronic pain syndromes. When effective,
the ease of use, general safety and
portability make it a preferred
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