PHARMANEX BIOPHOTONIC SCANNER INTRODUCTORY LETTER (July 1, 2002)
Early last year NSE was introduced to a very interesting technology that is on the leading edge of a new area called "BioPhotonics."

BioPhotonics is the non-invasive measurement of a ‘bio-marker’ inside the human body using light or photons to achieve the measurement.

Because of the heightened risks of invasive tests of all kinds, due to the prevalence of AIDS and other viruses and diseases, many researchers and companies are working on BioPhotonic measurement devices. Testing for everything from blood sugar levels to jaundice in babies will soon be measured from outside the body with light.

Several scientists at one of the top 50 research universities in the United States used BioPhotonics to discover that each molecule in the human body reflects a different kind of light. By using a very low power laser and shining it in the skin they could actually retrieve an “optical finger print” on very specific molecules that are of great interest to Pharmanex and to the entire nutritional research world. In short, for the first time ever, they developed the ability to measure antioxidant levels in living human tissue non-invasively. And with near instantaneous results.

This low power laser machine delivers a NUMBER that is the composite of your levels of antioxidants in your tissue. This is a huge step forward because up until now, the only measurements were done on the blood, which is an unreliable medium to measure in and is not the “Site of Action” where free radicals and antioxidants do their fighting. To be able to measure at the Site of Action has never been possible prior to the discovery and invention of this technology.

The ability to measure is the basis of science. We now control the future method of measurement for key nutrients that are of huge interest in the world today. We now possess the capability to further the development of nutritional products like LifePak and others in ways that were never possible before. We will extend our lead in providing the absolute best products in the entire world. We will dramatically increase the distance between our nearest competitors’ products and our own. We will now be able to prove to our consumers that taking Pharmanex products deliver real, MEASURABLE results. We will be able to motivate our customers to continue to consume our products more consistently and for longer periods of time. We will add value to our relationship with our customers in ways that other companies will not be able to match.

Several months ago Pharmanex acquired the Global exclusive rights to the use of this technology for the sale and testing of nutritional supplements on a WORLDWIDE BASIS. Pharmanex has paid millions of dollars for this acquisition and plans on worldwide deployment over the next 4 years.

We are on the verge of significant growth in our business. We have combined unique business elements, driven by the leading compensation plan in the world today. I have never been more excited than I am now and have never seen a brighter future for you than I see today.

Jack Peterson, VP Pharmanex Business Development

MORE DETAILS: The BioPhotonic Scanner

A Focus on Carotenoids
Carotenoids are a family of powerful antioxidant nutrients that have recently become the subject of huge interest in the scientific community. The orange pigment of carrots became the first of these molecules to be isolated, lending the name carotenoids to the entire family of compounds. Since then, more than 600 carotenoids have been discovered in nature, but only 18 are commonly present in the human body. While carotenoids represent a large percentage of antioxidant nutrients, there are many others that make up the body's antioxidant network, such as Vitamins C & E, Alpha-Lipoic Acid, and Flavonoids to name a few.

So why focus on carotenoids? Recently, the protective effects of carotenoids against free radical damage have stimulated intensive research on several specific carotenoids, lutein and lycopene in particular. Lutein is important for eye and cardiovascular health, while lycopene — the most potent antioxidant carotenoid — has far-reaching cell-protective and anti-aging benefits.

The Importance of Biological Measurements
The ability to measure is the basis of all science, so it is no surprise that health practitioners rely heavily on body measurements such as cholesterol readings and blood glucose levels. However, most of these methods are invasive and require drawing blood. With the increased awareness of viruses and other blood borne diseases, most health care professionals would rather use non-invasive means to gather wellness data.

BioPhotonics: New Possibilities in Laser Technology
Recent advancements in laser technology have opened a world of opportunities for health and wellness minded people across the globe. Through a process called BioPhotonics, it is possible to gather key wellness data by shining a laser-light onto the surface of a human hand. Because every molecule in the body interacts with light differently, each molecule reflects its own unique optical finger print. Scientists have understood this phenomenon of reflected light for decades, but it has only been in recent years, since the development of BioPhotonic Laser Technology, that they have been able to gather information at the "Site of Action" in living people.

The Creation of the Pharmanex BioPhotonic Scanner
After years of research and fine-tuning, several world-renowned physicists and engineers have perfected the world's first-ever carotenoid scanning device: the Pharmanex BioPhotonic Scanner. For the first time, carotenoid antioxidant levels can be measured in living human tissue. When the purified blue laser light strikes a carotenoid molecule in the palm of the hand, it is slightly shifted towards a green light because of the chemical make up of carotenoid molecules. Therefore, when a person's antioxidant levels are measured, the amount of reflected green light is gathered and assessed to produce a numeric reading known as a Body Defense Score.

This new technology allows for a non-invasive, rapid, accurate, and safe assessment of carotenoid levels in the skin, which correlate with levels of carotenoids and other antioxidants in your diet, blood and tissues. Since the BioPhotonic scanner measures carotenoid antioxidants, the Body Defense Score is an important indicator of the strength the body's overall antioxidant defense system.

Pharmanex Holds the Global Rights to BioPhotonic Technology
Pharmanex has acquired the global rights to this unique BioPhotonic Technology for the sale and testing of nutritional supplements. This provides Pharmanex a significant advantage over other nutritional companies because the Pharmanex BioPhotonic Scanner offers customers verifiable proof that LifePak and other Pharmanex products are truly making a difference in their overall health and well being. No other nutritional company can offer a technology that provides such convenient proof of the effectiveness of their antioxidant supplements.

LifePak: The Antioxidant Solution
LifePak is the only multivitamin and mineral supplement that has been clinically proven to promote antioxidant protection. Studies show that LifePak not only increases carotenoid levels, but also has an impact on antioxidants overall. Consumers of LifePak no longer have to rely on scientific studies alone. Now, for the first time ever, people who consume LifePak as instructed on the label, can get measured and see for themselves the positive benefits of using LifePak.

DISEASE PREVENTION? GREAT QUOTES & MORE DETAILS ON HOW THE SCANNER WORKS
“If, based on the results of this test, a physician determines a patient has low levels of macular pigment, that patient could be encouraged to increase consumption of foods or nutritional supplements containing lutein and zeaxanthin. It is possible that we could slow, or even prevent, onset of macular degeneration.”
- Paul S. Bernstein, M.D., Ph.D., assistant professor of ophthalmology and visual sciences at the University of Utah’s Moran Eye Center

Macular pigments in the eye exhibit extremely strong Raman signals when excited with blue laser, a phenomenon termed resonance enhancement.
“Lutein and zeaxanthin seemed uniquely suited for Raman spectrometry. The pigments literally glow green when a blue laser light shines on them. Under proper conditions, this resonance amplification can be as high as a factor of 10,000, turning a weak signal into a readily measured strong signal many times higher than background signals from other cells in the retina. This allows us to expose the retina to light exposure levels that are well within established safety ranges. As physicists, we’re trained to not to stare into lasers. But, when our colleagues at the Moran Eye Center pointed out the strong need to measure macular pigments in a non-invasive and objective way, we decided to take this unique laser approach.”
- Werner Gellermann, Ph.D., research professor in the University of Utah’s Department of Physics and associate director of the university’s Dixon Laser Institute